Abstract
Based on the anti-hepatitis C activity of 2'-C-methyl-adenosine and 2'-C-methyl-guanosine, a series of new modified purine 2'-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2'-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells.
Published by Elsevier Ltd.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry*
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Antiviral Agents / pharmacology*
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Cell Line
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Cell Survival / drug effects
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Hepacivirus / drug effects*
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Hepatitis C / drug therapy
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Humans
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Purine Nucleosides / chemical synthesis
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Purine Nucleosides / chemistry*
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Purine Nucleosides / pharmacology*
Substances
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Antiviral Agents
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Purine Nucleosides